Our most comprehensive thyroid profile.This test requires fasting for a minimum 8 hours, maximum 12 hours. Investigating plasma insulin levels, HbA1c levels and magnesium levels may provide further insight into thyroid symptoms or feelings of fatigue.
What is included in this test profile?
TSH, FT4, FT3, TT4, Thyroid Peroxidase Antibodies, Thyroglobulin Antibodies, Vitamin D, Vitamin B12, Folate, Ferritin and CRP as well as Reverse T3, Cortisol, Magnesium, Plasma Insulin levels + HbA1c.
Blood Test Explained
Please see below for a breakdown of test information, click each tab to find out more.
Ferritin is a protein found in the blood which carries iron. Like TIBC/UIBC, and transferrin saturation, it can tell us how much iron is stored in the body. The higher the level within a health screening, the greater the amount of iron stored. This test can be used to detect iron deficiency, and also conditions of iron excess (such as haemochromatosis). Ferritin can also be raised if inflammation is present in the body somewhere.
Thyroid related blood testing
TSH (thyroid stimulating hormone) is a hormone manufactured in the pituitary gland (found in the brain). It s role is to stimulate thyroxine production in the thyroid gland (found in the neck). A high level within a health screening is associated with an underactive thyroid gland (hypothyroidism) and a low level is found if the thyroid gland is over-active (hyperthyroidism). Changes in the TSH level alone can indicate underlying thyroid problems even if the thyroxine levels are normal.
Free T4 (free thyroxine) is the active form of thyroxine, released from the thyroid gland in the neck. Its role is to control metabolism - release of energy from all cells of the body. A lack of thyroxine leads to, for example, tiredness and weight gain, whereas an excess will lead to weight loss, rapid heart rate and anxiety. It is generally believed that this level (FT4) is the most reliable indicator of thyroid status - ie whether the gland is over-active (hyperthyroidism) or underactive (hypothyroidism).
Free T3 (Free Triiodothyronine) - This is one of two hormones produced by the thyroid gland. This measures the level of T3 that is 'free' and is able to regulate metabolism.
Thyroid Peroxidase Antibodies This is an enzyme found in the thyroid gland mostly. This allows the production of thyroid hormones.
TT4 A Total T4 measurement measures ALL of the T4 hormone – bound and free. Most endocrinologists find “Free T4” more useful, but we still include T4 in this profile as some doctors still specifically request it when investigating thyroid function.
Thyroglobulin Thyroglobulin is around half of the protein content for the Thyroid gland, which is used to store T4 and T3 Thyroid hormone molecules in the Thyroid. Conditions such as hyperthyroidism, Thyroiditis or goitre will cause an elevation of the serum Thyroglobulin. The main purpose of this testing is to indicate as a tumour marker for monitoring patients with differentiated thyroid cancer after a total thyroidectomy.
Reverse T3 There is controversy about the role of reverse T3 in thyroid illness. Conventional endocrinologists (hormone specialists) generally believe that knowledge of the level of this substance does not influence thyroid treatment decisions. The alternative view however is that reverse T3 is effectively 'antithyroid' - 'standard' T3 is the active thyroid hormone that stimulates the body's energy system (metabolism). Reverse T3 is a mirror image - it goes into cells, and instead of controlling metabolic processes it blocks the effect of T3. In this model, reverse T3 is effectively a hibernation hormone - in times of stress and chronic illness it lowers energy release from the cells - so normal thyroid levels with high reverse T3 may still result in hypothyroidism.
Cortisol As Cortisol decreases TSH, thereby decreasing thyroid hormone production, as well as inhibiting T4 to T3 conversion, measuring Cortisol is important and is now included in all Blue Horizon postal Thyroid Profiles.
Vitamin B12 is an important vitamin, essential for the normal functioning of many body processes. Deficiency can lead to anaemia (poor quality red blood cells) and neurological (nerve) disorders. It is most abundant in meat products so vegetarians are more vulnerable to deficiency of this vitamin. Pernicious anaemia develops if uptake of vitamin B12 into the blood from the gut is absent or severely impaired, and even if a diet rich in the vitamin is taken, deficiency will occur if this disease is present. Recent evidence suggests that mild deficiency is probably more common than previously thought. Mild deficiency may explain the presence of fatigue and a host of other limiting symptoms which is why we have included it within the PLUS V and PLUS X health screening profiles.
Vitamin D Vitamin D is an important vitamin, essential for good bone health. It is manufactured in the skin through sunlight exposure and is found in several foods. Prolonged Vitamin D lack can cause osteomalacia, a disease which causes severe structural deformities to the skeleton. Lower level Vitamin D deficiency can lead to a number of non-specific symptoms, including chronic pain, weak bones, frequent infections depression and fatigue. It has been estimated that between 50-70% of people living in the northern Europe (where daylight length reduces your chances of receiving adequate sunlight in the winter) are deficient in this vitamin by March each year which is why health screening for this important vitamin is essential.
Folate or Folic acid, is a B vitamin. It helps the body break down complex carbohydrates into simple sugars to be used for energy.
C Reactive Protein
High values of this 'inflammatory marker' are associated with inflammation from some cause. It is not an exact test, it is nonspecific. Very high readings are associated with polymyalgia rheumatica, a painful muscle ache affecting usually the upper arms or legs, and temporal arteritis - inflammation of the temporal artery which usually presents with severe headache in the temple area. Arthritis and infection can also lead to a raised inflammatory marker.
is very important and relates to the Thyroid gland in many ways, in fact the thyroid cannot function without magnesium as it is responsible for helping make more T4 within the Thyroid gland. It also helps in converting inactive T4 into an active form of T3, this allows the metabolism of body cells which are enhanced by T3 (unlike inactive T4).
A deficiency in Magnesium has also been linked to goiter and/or enlarged thyroid gland.
Weight loss with increased appetite Warm/clammy skin Shortness/loss of breath Feeling warm and sweating excessively Feeling hyperactive Rapid heartbeat Insomnia Osteoporosis Raised libido Irregular bowel movements Diarrhoea Thin hair Fertility problems Irritability
Fatigue Feeling cold constantly Weight gain and/or difficulty losing weight Brain fog Issues with Breathlessness Low basal temperature Insomnia Hair loss Raised cholesterol Low basal temperature Dry hair and skin Loss of libido Constipation Depression Mood swings Fertility problems
Information for this blood test
Test Name: Thyroid Premium Platinum
GP Referral: GP Referral is included
Target Turn Around Time in working days: 4-6 weeks
Test Inclusions: TSH, FT4, FT3, TT4, Thyroid Peroxidase Antibodies, Thyroglobulin Antibodies, Ferritin, Folate, Vitamin B12 (NOT ACTIVE B12), C Reactive Protein, Vitamin D (25-OH), Reverse T3, Plasma Insulin levels, HbA1c, Magnesium & Cortisol
Special Instructions: Fasting required (min 8 hours). SAMPLES MUST BE BACK WITH THE LABORATORY THE NEXT WORKING DAY.
Laboratory Notes: VACUTAINER ONLY
Further information. If you require any information on this test please call our team on: 0800 999 1110
How do you get a Blood Test?
1. Order Online. Select your required blood test from our test menu or call us on 0800 999 1110.
2. Arrange your sample collection appointment/blood draw.(ensure you have checked if you need to fast before attending your blood draw)
3. Wait for your blood test results, once they’re ready we will send them to you via email within the turnaround time stated on the website.
Do I need a Doctors referral to use this service?
No you do not require a Doctor’s Referral, we provide one when you have placed an order. This is free of charge, and a consultation is not required unless stated on certain tests.
How soon will I get my blood test results?
The turnaround time is a guide only, and will sometimes depend upon assay run schedules. Most results are provided within the time frame provided, but there may be technical difficulties, or the results may need to be re-run to check accuracy, or our Doctor may be held up passing comment. We can easily give you a status report, so please do email us or phone us to chase results, not the Laboratory itself.
Where can I get my blood taken if I order a vacutainer kit?
If you do not know of a professional nurse or phlebotomist we can refer you to a BMI Hospital or arrange a *Nurse home visit (charges will apply). PLEASE NOTE: You cannot attend at a Spire Hospital or the Doctors Laboratory (TDL) for your blood draw using our kit as our postal service is dealt with by a completely separate laboratory network.
What is the difference between reported and unreported results?
1. Reported results will be sent to the GP for comment, this process can take up to two working days to complete in addition to the stated turnaround time for results.
2. If you select unreported results, then you choose not to have the interpretation of our GP and they will be sent directly to you. This is advisable if you already have a specialist to share the results with or are able to interpret them yourself. In the event of any results being of a critical nature we will always be in contact to make you aware of this.
**Currently we are unable to provide Nurse visits due to the COVID-19 Pandemic.