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DNA Blue Thyroid Genetics

DNA Blue Thyroid Genetics


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  • DNA Blue Thyroid Genetics DNA Blue Thyroid Genetics

DNA Blue Thyroid Genetics

Quick Overview

Discover how your genes control the production of thyroid hormones, and how variations in your DNA might impact on their effectiveness, and ultimately your health. Your DNA is like an instruction manual responsible for controlling every single function that takes place in your body. Via a simple DIY cheek swab you will discover thyroid related markers in your unique DNA code that influence:

  • Your Pituitary Gland's receptivity to TRH which stimulates the secretion of TSH

  • Your Thyroid Gland's receptivity to TSH

  • Your Thyroid Gland's receptivity to TSH signalling

  • Conversion of T4 to T3

  • The clearing of RT3 from circulation

  • Your Body's response to stress

  • Detoxification of compounds that impact thyroid hormone levels

  • Your Body's response and susceptability to inflammation and infection, both of which affect thyroid function.

Along with the above information, we provide a Nutrition and Lifestyle Guide developed by specialists to help you to make the most out of the information and advice given.

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Additional Information

Search Description Discover how your genes control the production of thyroid hormones, and how variations in your DNA might impact on their effectiveness, and ultimately your health.
Extra Information Fasting not required.
Test Name DNA Blue Thyroid Genetics
Profile or Test? Profile
Test Inclusions

DIO1 - Thyroid Hormone Activation

“D1” is largely expressed in the liver and kidneys. It is responsible for the clearance of rT3 from circulation, and for facilitating the conversion of T4 to T3 in plasma and surrounding tissue. This process requires selenium and iodine for optimum function. Here we look at two variants linked to poor conversion of T4 to T3 and
reduced clearance of RT3.

DIO2 - Thyroid Hormone Activation

“D2” is importantly expressed in the central nervous system, pituitary, brown fat tissue and muscle, and responds to changes in thyroid levels. D2 is responsible for the ‘local’ conversion of T4 to T3 in the thyroid, placenta and brain. It requires selenium and iodine to function optimally. Here we look at two different variants linked to decreased T4 and low mood in certain individuals.

COMT - Inactivation of Stress Hormones and Oestrogen

COMT is one of the main inactivating enzymes of stress hormones and oestrogen in the body. COMT variants cause slow clearance of stress hormones and oestrogen leading to high oestrogen and stress hormone levels which may also be linked to thyroid hormone dysfunction.

FKBP5 - Cortisol Regulation

FKBP5 is an important stress-regulating gene responsible for lowering cortisol levels after a stress response. Variants are associated with prolonged and increased symptoms of stress, which may be due to delayed lowering of cortisol levels.

PDE8B - TSH Signalling

PDE8B is found in the thyroid but not the pituitary, and is involved in TSH signalling. It is thought that the variant decreases the response of the thyroid gland to TSH stimulation

TNF-a - Inflammation

TNF-a is an inflammatory cytokine that helps regulate the immune reaction involved in inflammation, giving rise to fever and inhibiting tumour growth. If poorly controlled, it may be implicated in a number of autoimmune disorders. Variants in TNFa are associated with overreactive immune responses and prolonged inflammation.

TSHR - Thyroid Stimulating Hormone (TSH) Receptor

The TSHR gene plays a central role in thyroid metabolism bycontrolling the thyroid gland’s receptivity to TSH. Variants in this gene have been linked to hyperthyroidism, particularly to Graves’ Disease (GD).

TRHR - Thyrotropin Releasing Hormone (TRH) Receptor

Responsible for the body’s receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately regulates thyroid hormone levels. Variants have been shown to affect TSH levels.

The information provided is strictly for educational purposes and is not intended for diagnostic or treatment purposes and should not
be used as a substitute for professional medical advice. Use the information provided solely at your own risk. If you have any concerns about your health, please consult a qualified health professional.

Pathology Sample Swab
Target Turn Around Time in working days 4-6 weeks
Laboratory Notes THIS TEST IS ONLY AVAILABLE FOR 18'S AND OVER. Full instructions included for swabbing your cheek
Special Instructions No
Special Notes -
GP Referral Yes Included
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    1. Q: Do I need a Doctor’s Referral to use this service?

      A: No you do not require a Doctor’s Referral, we provide one when you have placed an order. This is free of charge, and a consultation is not required unless stated on certain tests.

    1. Q: So all I need to do is order online or over the phone, and then prepare for my blood draw.. Seriously, is that it?

      A: Yes, the process is that simple.

    1. Q: How soon will I get my results?

      A: The turnaround times are clearly stated in working days on all of our blood test pages, this is the timeframe that we estimate for turnaround of results.

    1. Q: Do I get a copy of my results?

      A: You will receive a PDF copy of your laboratory certificate which prints onto A4 paper. If you would like a paper copy, let us know and we will post one out to you.

    1. Q: Pathology points

      A: Pathology points are points we provide when purchasing a test to add more value to your order. Each test will show how many Pathology Points you will earn if purchased. Each Pathology Point is worth £1.00 and can only be redeemed against future blood test orders.

    1. Q: What is the difference between reported and unreported results?

      A: Reported results will be sent to the GP for comment, this process can take up to two working days to complete in addition to the stated turnaround time for results. If you select unreported results, then you choose not to have the interpretation of our GP and they will be sent directly to you. This is advisable if you already have a specialist to share the results with or are able to interpret them yourself. In the event of any results being of a critical nature we will always be in contact to make you aware of this.

8 Postal Testing Guarantees

Postal Testing Guarantees from Blue Horizon Medicals.

Accreditation Guarantee
The results that we provide you with are guaranteed to be from accredited laboratories

Despatch Guarantee
We will send your testing kit out the same day as we receive your order if we receive by 3pm Mondays through to Fridays, excluding bank holidays.

Change of Mind Guarantee
Should you change your mind about testing before we dispatch your test kit we can provide you with a full refund.

Returns Guarantee
If we have dispatched your kit, you can return it to our returns address below within 30 days for a full refund if it is unused and undamaged. If it is incomplete, used or damaged in any way we may deduct a fee of £5. If you have chosen for us to dispatch your kit to you by express delivery, we will deduct the charge for that. You may keep the A6 card insert with the attached information card and promotional pathology point chocolate coin with our compliments.

If you wish to cancel your order after 30 days have passed from when the order is placed you can do so by returning it to our returns address below. We are unable to refund you but can credit you with the equivalent value of your purchase in Pathology Points which can be used for future pathology testing for yourself or a guest on any participating Blue Horizon Medicals website. If your kit is returned, incomplete, used or damaged in any way, we may deduct the equivalent of £5 in Pathology Points.

Phlebotomy Money Back Guarantee
If you elect to use our nurse home visit service or BMI hospital phlebotomy service we will guarantee you your money back if the nurse or support staff do not manage to successfully collect a sample. We can however only offer this money back phlebotomy guarantee once per patient to make the guarantee fair for all.

Finger-Prick Try Again Guarantee
If you are not successful in obtaining a viable finger prick sample (1 in 10 are unsuccessful) we find that in situations where finger-prick instructions have been followed correctly and success has not been met, then a second attempt will most likely meet with the same fate. But the choice is yours – so if you want to take this risk we can send out another finger-prick kit free of charge for you, but if you fail again and request a refund we will need to deduct an administration charge of £5.
Alternatively of course we can look at phlebotomy options for you such as a nurse visit, attendance at a BMI hospital or you can arrange your own vacutainer sample collection and we won’t charge you for the failed finger-prick kit.

One year usage Guarantee
You have up to one year from when you have purchased the kit to return it to the Laboratory in the supplied envelope. After a year has expired if you still would like your test please contact us and we’ll see what we can do for you. We may just need to check expiry dates of batch components.

Refunds Guarantee
Refund requests must be made by email to assistance@bluehorizonmedicals within the timeframes stated above together with a reason for the request. Unused kits should be sent to Blue Horizon Medicals, Tavyside Health Centre, Abbey Rise, Tavistock PL19 9FD. Please do not use the supplied envelopes as these go to the laboratory and may incur further charges. We guarantee that any refunds or pathology points due to be credited will be done so within seven working days of our receipt of the kit.
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